The new accounting for expected adjusted effect test (AEAE test) has higher positive predictive value than a zero-order significance test

Abstract Objective The present simulation study aimed to assess positive predictive value (PPV) and negative (NPV) for our newly introduced Accounting Expected Adjusted Effect test (AEAE test) compare it PPV NPV a traditional zero-order significance test. Results AEAE exhibited greater compared test, especially with strong true adjusted effect, low prior probability, high degree of confounding, large sample size, reliability in the measurement predictor X outcome Y, confounder Z. on other hand, higher NPV, except some combinations confounding or Z X/Y, which case can be completely uninformative. Taken together, findings demonstrate desirable statistical properties